Microsoft CEO expects volumes on Windows Phone to "ramp quickly"

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Sharon Osbourne has double mastectomy
















LONDON (AP) — Sharon Osbourne says she had a double mastectomy after learning she carries a gene that increases the risk of developing breast cancer.


Osbourne told Hello! magazine that “I didn’t want to live the rest of my life with that shadow hanging over me.”













The 60-year-old “America’s Got Talent” judge, who had colon cancer a decade ago, said that without the surgery, “the odds are not in my favor.”


She added: “It’s not ‘pity me,’ it’s a decision I made that’s got rid of this weight that I was carrying around.”


The magazine went on sale Monday.


Osbourne, husband Ozzy and children Jack and Kelly became rock’s most famous clan thanks to reality show “The Osbournes” a decade ago.


Jack Osbourne, 26, was recently diagnosed with multiple sclerosis.


Entertainment News Headlines – Yahoo! News



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BioMarin genetic disorder drug meets main goal, shares jump
















(Reuters) – BioMarin Pharmaceutical Inc said a late-stage trial of its experimental genetic disorder drug met the main goal of improving patients’ walking ability when administered weekly, sending the company‘s shares up 25 percent in premarket trading.


The drug, called GALNS, however, did not show any improvement over a placebo when administered every other week.













The trial, named MOR-004, showed that weekly doses of the drug at 2 mg/kg improved the six-minute walk distance of patients by 22.5 meters over the placebo.


However, patients getting the same dose every other week did not show any meaningful or statistically significant change compared to the placebo.


The disorder – Mucopolysaccharidosis Type IVA (MPS IVA), or Morquio A Syndrome – is a rare, inherited disorder caused by the deficiency of a particular enzyme, leading to skeletal dysplasia, short stature and joint abnormalities.


The drug was also tested in another extension trial that showed its benefits continued to improve with further dosage, BioMarin said in a statement.


GALNS was generally well-tolerated and adverse events were similar to those seen in the trials of other enzyme replacement therapies. There were no deaths and no patients withdrew from the study due to adverse events.


BioMarin now plans to submit marketing applications for the drug, starting from the first quarter of 2013.


The company currently has four drugs in the market, two of which are for treating other metabolic disorders caused by the absence of certain enzymes.


Shares of the company closed at $ 37.41 on the Nasdaq on Friday, and were trading at $ 47 before markets opened on Monday. (Reporting by Esha Dey in Bangalore; Editing by Joyjeet Das)


Medications/Drugs News Headlines – Yahoo! News



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AnnaLynne McCord to get “Scorned” With Billy Zane in new thriller

























LOS ANGELES (TheWrap.com) – AnnaLynne McCord is about to become a woman “Scorned.”


“90210″ star McCord has signed on for the revenge thriller “Scorned,” alongside “Titanic” star Billy Zane and Viva Bianca from Starz’s “Spartacus.”





















McCord and Zane will play Sadie and Kevin, a couple whose romantic weekend at a lake house takes a sideways turn when a text message from Sadie’s best friend (played by “Bianca”) to Kevin reveals a lurid love affair between the two, sending Sadie on a vengeance spree.


“Scorned” will be directed by Mark Jones, the creator and director of the beloved “Leprechaun” horror-movie series.


Jones likened the project to “sophisticated” thrillers such as “Fatal Attraction” and “Misery.”


“Having done horror with comedy, I wanted to delve into something more sophisticated along the lines of ‘Fatal Attraction’ and ‘Misery,’ and develop a multi-dimensional, twisted character in our lead villain (McCord), who I feel brings an original and incredibly unique take on her character,” Jones said.


Lightning Entertainment will handle international sales of the film, with Lightning’s Audrey Delaney and Marc Bienstock executive-producing.


Movies News Headlines – Yahoo! News



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Israel’s Neuronix offers new Alzheimer’s treatment

























TEL AVIV (Reuters) – Israel-based Neuronix, which has developed a non-invasive medical device to help to treat Alzheimer’s disease, expects the system to be approved by the U.S. Food & Drug Administration in late 2014.


The device, which combines electromagnetic stimulation with computer-based cognitive training, is already approved for use in Europe, Israel and several Asian countries. In Singapore it is approved for clinical trial use and the application for registration of the product is still under evaluation.





















“You stimulate the brain on a biological level as well as on a cognitive level,” Neuronix CEO Eyal Baror told Reuters, saying this double approach created longer-lasting benefits.


The device, which consists of a chair containing an electronic system and software in the back and a coil placed at the head, has been tested on mild to moderate Alzheimer’s patients who suffer from dementia but are not totally dependent.


The system is in trials at Harvard Medical School/Beth Israel Deaconess Medical Centre. Patients are treated for one hour a day, five days a week over six weeks.


“We see improvement lasting for 9-12 months and the good thing is that patients can return and undergo treatment again,” Baror said. “If out of 10 years the patients have left to live we can keep them at home in a relatively mild state of the disease for three, four, five years, it’s a lot.”


According to Alvaro Pascual-Leone, director of the hospital’s Berenson-Allen Centre for Non-invasive Brain Stimulation, brain stimulation – or transcranial magnetic stimulation – involves a very low current applied to a specific part of the brain and is approved by the FDA for treatment of a variety of ailments and diagnostic applications.


“The application in Alzheimer’s disease and in combination with cognitive training is novel,” Pascual-Leono said in a phone interview from Boston.


About 20 percent of patients experience a mild headache but there are no long-term negative effects, he said.


Pascual-Leone, who is principal investigator in the Harvard trial, said that of 12 patients in the study, six received the real treatment and all showed cognitive improvement. Their improvement was significantly more than the average seen in patients taking just medication, he said.


The study’s results will be submitted for publication in the coming weeks and a follow-up study on 30 patients is planned.


Neuronix received European approval several months ago and has installations in the UK and Germany. In Israel, a few dozen patients are being treated with the device.


The U.S. trials are expected to run till the end of 2013. Neuronix is also running a trial in Israel for pre-Alzheimer’s patients.


The company expects to sell half a dozen systems in the second half of 2012 and three dozen in 2013. In Israel, the treatment costs $ 6,000.


“Our target for becoming profitable is in parallel to entering the U.S. market around 2015,” Baror said.


Neuronix has raised $ 8 million from private individuals as well as in grants from the Israeli Chief Scientist’s Office and is exploring options to raise more money in the coming year, including the possibility of going public.


(This version of the October 24 story corrects paragraph two that company corrects to say that in Singapore, device is approved for clinical trial use and its application for registration of the product is under evaluation, not that device is approved for commercial use.)


(Reporting by Tova Cohen; editing by Stephen Nisbet)


Diseases/Conditions News Headlines – Yahoo! News



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Campaigning for victory, Romney speeches shift

NEWINGTON, N.H. (AP) — From an airport runway on a cold New Hampshire morning, Republican Mitt Romney faced 2,000 supporters and delivered the same speech he had given the day before — three times on the day before, actually.

"I won't just represent one party, I'll represent one nation," the presidential candidate declared Saturday for the fourth time in 36 hours as swing-state Republicans cheered, most of them hearing his pledge for the first time.

The Romney stump speech, like that of his opponent, is a carefully crafted 15 minutes that opens a window into the strategy behind his second presidential bid. And for Romney, it is a constantly evolving tool that has shifted sharply in recent weeks to appeal to the political center.

Let there be no doubt that Romney, who once described himself as "severely conservative," is aggressively courting the narrow slice of undecided voters — largely women and moderates — who have yet to settle on a candidate.

From central Florida to central Iowa, the stories Romney tells in daily campaign stops have changed to include intimate personal details. The emphasis on his business career has been forgotten. And while he repeatedly jabs President Barack Obama, he devotes as much time to an optimistic vision for an America that would "come roaring back" under a Romney administration.

"Come walk with me. Walk together to a better place," Romney said Saturday with the confidence of a man who has used the line several times before.

The year before, Romney launched his presidential campaign in New Hampshire with a very different message. At the time, he referenced his 25-year business career in almost every speech, suggesting he was uniquely qualified to repair the nation's ailing economy.

It was all economy, all the time.

"This, for me, is not about the next step in my political career," the former Massachusetts governor who also ran for president in 2008 told a New Hampshire audience in September 2011. "I don't have a political career. I spent 25 years in business."

But three days before Election Day, Romney the businessman had completed the journey to becoming Romney the politician.

He drew heavily from his experience in Massachusetts, devoting just a few sentences to his business career. He cited his work to cut taxes, create jobs, cut the deficit, improve education. And above all, he emphasized his ability to work with the Democrats who dominated state politics.

"Instead of attacking each other, we went to work to try to solve our problems," Romney said.

While heavily scripted, the daily stump speech also offers the occasional insight. Romney often slips dry humor into his speeches along with awkward words that sometimes raise eyebrows. He loves to begin sentences with, "In the final analysis," references "quartiles," and often proclaims, "Wow!"

On Saturday he joked that his New Hampshire supporters should "harangue" his friends. Later Saturday in Iowa, he noted that Sen. Chuck Grassley recently hit a deer with his car and asked, "Was it delicious?"

Romney has never possessed the same charm at the podium that allowed successful campaigners in the past — Ronald Reagan, Bill Clinton and Barack Obama among them — to connect with voters. But, in the speeches themselves, Romney has tried to address that weakness. This week he has repeatedly declared that "talk is cheap."

He also uses his speeches to address the regular criticism that he's not offering enough specifics. In virtually every rally since late summer, he outlines a five-point plan to get the nation's economy going. It's a general list of talking points that is largely in line with Obama's, albeit with different focuses.

First, Romney says he'd push an energy agenda that focuses on oil, gas and coal. He'd then adopt a trade policy that opens markets in Latin America and cracks down on China. The Republican also supports training and education programs that work around teachers unions. He'd also get the nation "on track" to a balanced budget. And finally, he would "champion small business."

Perhaps most striking is the shift in the personal stories he tells to help connect with voters.

For several months, on a near-daily basis, he shared underdog stories of oilmen and food industry magnates. In recent weeks, he has spoken instead about Boy Scouts who watched a space shuttle explosion, talked of a sister who has raised a child with Down syndrome and devoted a special mention to single mothers.

"I think of all the single moms who are scrimping and saving to make sure they have a good meal on the table at the end of the day for their children," he said this week. "We're a nation of people with great hearts who care very deeply about things bigger than ourselves."

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Syria army quits base on strategic Aleppo road

























BEIRUT (Reuters) – The Syrian army abandoned its last base near the northern town of Saraqeb after a fierce assault by rebels, further isolating the strategically important second city Aleppo from the capital.


But in a political setback to forces battling to topple President Bashar al-Assad, the United Nations said the rebels appeared to have committed a war crime after seizing the base.





















The opposition Syrian Observatory for Human Rights said on Friday government troops had retreated from a post northwest of Saraqeb, leaving the town and surrounding areas “completely outside the control of regime forces”.


It was not immediately possible to verify the reported army withdrawal. Authorities restrict journalists’ access in Syria and state media made no reference to Saraqeb.


The pullout followed coordinated rebel attacks on Thursday against three military posts around Saraqeb, 50 km (30 miles) southwest of Aleppo, in which 28 soldiers were killed.


Several were shown in video footage being shot after they had surrendered.


“The allegations are that these were soldiers who were no longer combatants. And therefore, at this point it looks very likely that this is a war crime, another one,” U.N. human rights spokesman Rupert Colville said in Geneva.


“Unfortunately this could be just the latest in a string of documented summary executions by opposition factions as well as by government forces and groups affiliated with them, such as the shabbiha (pro-government militia),” he said.


Video footage of the killings showed rebels berating the captured men, calling them “Assad’s dogs”, before firing round after round into their bodies as they lay on the ground.


Rights groups and the United Nations say rebels and forces loyal to President Bashar al-Assad have committed war crimes during the 19-month-old conflict. It began with protests against Assad and has spiraled into a civil war which has killed 32,000 people and threatens to drag in regional powers.


The mainly Sunni Muslim rebels are supported by Sunni states including Saudi Arabia, Qatar and neighboring Turkey. Shi’ite Iran remains the strongest regional supporter of Assad, who is from the Alawite faith which is an offshoot of Shi’ite Islam.


STRATEGIC BLOW


Saraqeb lies at the meeting point of Syria’s main north-south highway, linking Aleppo with Damascus, and another road connecting Aleppo to the Mediterranean port of Latakia.


With areas of rural Aleppo and border crossings to Turkey already under rebel control, the loss of Saraqeb would leave Aleppo city further cut off from Assad’s Damascus powerbase.


Any convoys using the highways from Damascus or the Mediterranean city of Latakia would be vulnerable to rebel attack. This would force the army to use smaller rural roads or send supplies on a dangerous route from Al-Raqqa in the east, according to the Observatory’s director, Rami Abdelrahman.


In response to the rebels’ territorial gains, Assad has stepped up air strikes against opposition strongholds, launching some of the heaviest raids so far against working class suburbs east of Damascus over the last week.


The bloodshed has continued unabated despite an attempted ceasefire, proposed by join U.N.-Arab League envoy Lakhdar Brahimi to mark last month’s Muslim holiday of Eid al-Adha.


In the latest in a string of fruitless international initiatives, China called on Thursday for a phased, region-by-region ceasefire and the setting up of a transitional governing body – an idea which opposition leaders hope to flesh out at a meeting in Qatar next week.


Veteran opposition leader Riad Seif has proposed a structure bringing together the rebel Free Syrian Army, regional military councils and other rebel forces alongside local civilian bodies and prominent opposition figures.


His plan, called the Syrian National Initiative, calls for four bodies to be established: the Initiative Body, including political groups, local councils, national figures and rebel forces; a Supreme Military Council; a Judicial Committee and a transitional government made up of technocrats.


The initiative has the support of Washington. U.S. Secretary of State Hillary Clinton called on Wednesday for an overhaul of the opposition, saying it was time to move beyond the troubled Syrian National Council.


The SNC has failed to win recognition as the legitimate representative of the Syrian people and Clinton said it was time to bring in “those on the front lines fighting and dying”.


(Additional reporting by Oliver Holmes in Beirut and Stephanie Nebehay in Geneva; Editing by Jon Boyle)


World News Headlines – Yahoo! News



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Google's Android software in 3 out of 4 smartphones

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